Author(s): Li, YQ (Li Yun-qi); Zhang, N (Zhang Ning); Chen, DF (Chen De-fu); Qiu, HX (Qiu Hai-xia); Zeng, J (Zeng Jing); Wang, N (Wang Na); Gu, Y (Gu Ying)

Source: SPECTROSCOPY AND SPECTRAL ANALYSIS Volume: 42 Issue: 8 Pages: 2649-2656 DOI: 10.3964/j.issn.1000-0593(2022)08-2649-08 Published: AUG 2022

Abstract: Background: Ultraviolet radiation is one of the key conditions to maintaining bone health, but it has not been paid enough attention to in the field of osteoporosis because of the wide traditional ultraviolet spectrum. With the development of LED technology, all kinds of narrowband LED spectra can be adjusted arbitrarily. Materials and methods: In this study, we established a newly designed LED device with a narrow band spectrum to investigate the effects of ultraviolet LED on bone metabolism, bone morphology and skin of osteoporotic rats. We have set up a total of unovariectomized rats (n=24) and ovariectomized rats (n=36). The unovariectomized rats were then divided into the sham operation group (Sham, n=12) and the detection model group (Sham, n=12). The ovariectomized rats were divided into either the LED irradiation group (LED, n=12) the no treatment group (OVX, n=12), or the detection model group (OVX, n=12). The LED Irradiation parameters (0. 8 mW . cm(-2), 1 000 s, twice a week). Results: Compared with the sham group, the expression of vitamin D mRNA, serum bone ALP, serum 25(OH)D-3 and serum PINP increased significantly, the serum PTH and serum TRAP decreased significantly. Conclusion: Our results show that irradiation with the new ultraviolet LED device can significantly increase the level of 25(OH)D-3 in blood, promote bone formation and inhibit bone resorption without adverse effects on rat skin.

Accession Number: WOS:000852883200050

ISSN: 1000-0593

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