Author(s): Tang, W (Tang, Wei); Fu, Y (Fu, Ying); Huang, YK (Huang, Yukun); Li, YZ (Li, Yuanzhe); Song, YW (Song, Yawen); Xi, X (Xi, Xin); Yu, YD (Yu, Yude); Su, YZ (Su, Yuezeng); Yan, F (Yan, Feng); Guo, XJ (Guo, Xiaojun)

Source: NPJ FLEXIBLE ELECTRONICS Volume: 6 Issue: 1 Article Number: 18 DOI: 10.1038/s41528-022-00149-9 Published: MAR 18 2022

Abstract: Developing organic field-effect transistor (OFET) biosensors for customizable detection of biomarkers for many diseases would provide a low-cost and convenient tool for both biological studies and clinical diagnosis. In this work, design principles of the OFET transducer for biosensors were derived to relate the signal-to-noise ratio (SNR) to the device-performance parameters. Steep subthreshold swing (SS), proper threshold voltage (V-th), good-enough bias-stress stability, and mechanical durability are shown to be the key prerequisites for realizing OFET bio-sensors of high transconductance efficiency (g(m)/I-D) for large SNR. Combining a low trap-density channel and a high-k/low-k gate dielectric layer, low-temperature (<100 degrees C) solution-processed flexible OFETs can meet the performance requirements to maximize the g(m)/I-D. An extended gate-structure OFET biosensor was further implemented for label-free detection of miR-21, achieving a detection limit below 10 pM with high selectivity at a low operation voltage (<1 V).

Accession Number: WOS:000770628200003

eISSN: 2397-4621

Full Text: https://www.nature.com/articles/s41528-022-00149-9